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Pharmacological activity of the hydroalcoholic extract from Hovenia dulcis thunberg fruit and the flavonoid dihydromyricetin during hypercholesterolemia induced in rats BJPS
Pinto,Juliana Tensol; Oliveira,Tânia Toledo de; Alvarenga,Luana Farah; Barbosa,Adriano Simões; Pizziolo,Virgínia Ramos; Costa,Marcelo Rocha da.
Cerebrovascular accidents and coronary artery disease are the leading causes of cardiovascular mortalities in Brazil and high levels of LDL cholesterol are one of the main risk factors. In this context, several plant extracts and natural substances have shown promise as cholesterol-lowering. The objective of this study was to evaluate the potential of the hydroalcoholic extract of the fruit of H. dulcisand of dihydromyricetin in cholesterol reduction in hypercholesterolemic rats. Forty-two Wistar male rats were distributed into seven groups of six animals that received diets supplemented with 1% cholesterol and 0.3% cholic acid, with the exception of the control group, which received conventional diets. Animals were treated with oral suspensions...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hovenia dulcis/pharmacognosy; Hovenia dulcis/hydroalcoholic extract/ cholesterol reduction; Hovenia dulcis/flavonoid dihydromyricetin/cholesterol reduction; Dihydromyricetin/cholesterol reduction; Hypercholesterolemia/experimental study; Medicinal plants.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400727
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Protective effect of guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine) against cisplatin-induced hypercholesterolemia in rats BJPS
Nora,Cleice Dalla; Danelli,Daiane; Souza,Lucéia Fátima; Rios,Alessandro de Oliveira; Jong,Erna Vogt de; Flôres,Simone Hickmann.
The present study was the first to examine the protective effect and antioxidant potential of two fruits native to the south of Brazil, namely guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanumSabine), with respect to reducing the effects of cisplatin-induced hypercholesterolemia in male Wistarrats. The cisplatin-treated animals showed high glucose, LDL cholesterol, oxidized LDL cholesterol and total cholesterol levels. These native fruits reversed the increase in these parameters. The fat levels in the liver improved with supplementation with the fruits, and there were no differences in the thiobarbituric acid reactive substances (TBARS), creatinine, urea or HDL cholesterol levels, nor in the weight of the organs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Guabiju/protective effect; Red guava/protective effect; Myrcianthes pungens (O. Berg) D; Legrand/protective effect; Psidium cattleyanum Sabine/protective effect; Hypercholesterolemia/experimental study; Cisplatin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300483
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